Frontiers

Mechanisms underlining R-loop biology and implications for human disease

R-loops are three-stranded non-canonical nucleic acid structures composed of nascent RNA hybridized with the template DNA strand, leaving the non-template DNA strand displaced. These structures play ...
PNAS

R-loop functions in Brca1-associated mammary tumorigenesis

Despite a positive correlation between R-loops and tumorigenesis, the presumed causality is not experimentally validated. Using a transgenic mouse model in which accumulated R-loops are removed in ...
Frontiers

Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the ...
PNAS

NF-κB–induced R-loop accumulation and DNA damage select for nucleotide excision repair deficiencies in adult T cell leukemia

Edited by Robert Gallo, Institute of Human Virology and Departments of Medicine and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, and approved January 7, 2021 ...
eLife

Human immunodeficiency virus-1 induces host genomic R-loop and preferentially integrates its genome near the R-loop regions

Altmetric provides a collated score for online attention across various platforms and media. See more details Although HIV-1 integration sites favor active transcription units in the human genome, ...
eLife

The Smc5/6 complex counteracts R-loop formation at highly transcribed genes in cooperation with RNase H2

The R-loop is a common transcriptional by-product that consists of an RNA-DNA duplex joined to a displaced strand of genomic DNA. While the effects of R-loops on health and disease are well ...