We applied the principle of synthetic lethality to discover a novel strategy for cancer treatment for patients with BRCA1 or ...

We played a major role in revealing the biochemical steps of the RAS-RAF-MAP kinase pathway. We identified one of the major ...

PI3 kinase is a lipid signalling enzyme which plays a key role in the development and progression of many cancers as a result ...

We transformed care for advanced prostate cancer, by validating inhibitors of androgen production as an effective cancer ...

We led major clinical trials in radiotherapy and imaging which have changed standard clinical practice for cancer treatment.

We provided the first conclusive evidence that the basic cause of cancer is damage to DNA. The discovery changed scientific opinion dramatically and marked a turning point for cancer research.

We played a leading role in clinical trials that demonstrated the effectiveness of aromatase inhibitors in breast cancer, and in identifying and validating biomarkers to determine who could benefit ...

Professor Eeles's goal is to develop new tests that could be used in prostate cancer screening, helping to identify men at a ...

We played a major role in characterising the BRAF gene and its role in cancer, increasing our understanding of malignant melanoma.

We pioneered the application of evolutionary biology to cancer and established cancer stem cells as the units of natural selection.

We identified the breast cancer gene BRCA2, which enabled families with a history of breast cancer to be assessed for future risk, and laid the groundwork for developing novel forms of therapy for ...

We have an outstanding record of scientific achievement dating back more than 100 years. Here are some of our most influential discoveries, all of which have played an important role in shaping our ...