R-loops are three-stranded non-canonical nucleic acid structures composed of nascent RNA hybridized with the template DNA strand, leaving the non-template DNA strand displaced. These structures play ...

Despite a positive correlation between R-loops and tumorigenesis, the presumed causality is not experimentally validated. Using a transgenic mouse model in which accumulated R-loops are removed in ...

DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the ...

Edited by Robert Gallo, Institute of Human Virology and Departments of Medicine and Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, and approved January 7, 2021 ...

Altmetric provides a collated score for online attention across various platforms and media. See more details Although HIV-1 integration sites favor active transcription units in the human genome, ...

Type V CRISPR-Cas interference proteins use a single RuvC active site to make RNA-guided breaks in double-stranded DNA substrates, an activity essential for both bacterial immunity and genome editing.

Is your feature request related to a problem? Please describe. This issue was mentioned in #181 (under known limitations, first bullet), but I thought I'd make it a feature request. I often use a for ...

We are not covering much about the programming side of R today. However `for` loops are useful even for interactive work. If you intend to take your knowledge of R further, you should also investigate ...