New to the 2.5 release is improved support of Microsoft Project for Windows. You can open native MS Project files and exchange data using MS Project’s XML and MPX support.

We use MS Project Server. It does the job but its a piece of crap. Might have something to do with the fact that we're using the 2003 version. Whatever you go with, get one with a web interface ...

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The MS project has an intuitive interface and is a highly regarded software solution to help assist your tasks.