As noted in a past Edge blog post, SDSM provides additional security features that allows you to disable just-in-time Javascript and then enable Controlflow-Enforcement Technology (CET) instead.

Why Disable the Pop-Up Blocker in Edge? Normally, you do not have to disable Edge's pop-up blocker. It's helpful to block obtrusive advertisements and alerts, many of which are phishing attempts.

When you want to prevent users from running extensions on Microsoft Edge, use this guide to disable the feature.