Frontiers

Mechanisms underlining R-loop biology and implications for human disease

R-loops are three-stranded non-canonical nucleic acid structures composed of nascent RNA hybridized with the template DNA strand, leaving the non-template DNA strand displaced. These structures play ...
Frontiers

Sensing R-Loop-Associated DNA Damage to Safeguard Genome Stability

DNA transcription and replication are two essential physiological processes that can turn into a threat for genome integrity when they compete for the same DNA substrate. During transcription, the ...
eLife

Human immunodeficiency virus-1 induces host genomic R-loop and preferentially integrates its genome near the R-loop regions

Altmetric provides a collated score for online attention across various platforms and media. See more details Although HIV-1 integration sites favor active transcription units in the human genome, ...
PNAS

Keeping Cas9 out of the (R-)loop

Studying Acrs not only provides fundamental insights in the evolutionary arms race between prokaryotes and their viruses, but additionally illuminates the key mechanisms of Cas proteins. Simplified ...
PNAS

Cytosine deamination and base excision repair cause R-loop–induced CAG repeat fragility and instability in Saccharomyces cerevisiae

R-loops form when transcribed RNA remains bound to its DNA template to form a stable RNA:DNA hybrid. Stable R-loops at a CAG/CTG repeat tract, a sequence that can expand to cause human disease, cause ...
GitHub

Name already in use

We are not covering much about the programming side of R today. However `for` loops are useful even for interactive work. If you intend to take your knowledge of R further, you should also investigate ...